Refast Ortho Tablet is a combination of Methylsulphonyl Methane Alpha Lipoic acid Glucosamine and Methylcobalamin.  MSM Methylsulphonyl Methane is used for chronic pain osteoarthritis joint inflammation rheumatoid arthritis osteoporosis bursitis tendonitis tenosynovitis musculoskeletal pain muscle cramps.Glucosamine is a nutritional supplement used in the treatment of osteoarthritis and rheumatoid arthritis. Glucosamine is a naturally occurring chemical found in the human body in the fluid that is around joints. It stimulates the production of cartilage which leads to joint repair. It maintains elasticity strength and resilience of the cartilage in articular (movable) joints. In addition to relieving pain and improving joint function glucosamine also slows the breakdown of joints in people with osteoarthritis who take it long-term. It also keeps osteoarthritis from getting worse as quickly as it otherwise might. People who take glucosamine are less likely to need total knee replacement surgery. Alpha Lipoic acid is a potent antioxidant and also exerts anti-inflammatory effects. Methylcobalamin besides improving bone mineralization also prevents the inflammation of the joint by inhibiting the immune cells responsible for inflammatory reactions. Use under medical supervision.